GROWTWO (GHRP-2)

Contents Vial: GHRP-2 (Growth Hormone Releasing peptide-2) 5mg.
Ampoule: Sterile water for injection 2ml.
Administration Intramuscular or subcutaneous injection.
Storage Store at room temperature away from heat and direct sunlight prior to reconstitution. Refrigerate between 2-8’C post reconstitution.
Dosage Adult: SC Growth hormone deficiency Initial: 6 mcg/kg/day. May increase dose gradually. Max: 12.5 mcg/kg/day. HIV-associated wasting or cachexia 5 mcg/kg/day at bedtime. May take on alternate days for patients at increased risk of adverse effects. Max: 5 mg/day.
Contraindications Acute critical illness due to heart or abdominal surgery, multiple accidental trauma or respiratory failure; active neoplasms, proliferative or preproliferative diabetic retinopathy; lactation; patients with closed epiphyses. Intracranial lesions. Patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment.
Special Precautions Monitor thyroid function; benign intracranial hypertension. DM; may require dose reduction in insulin. Pregnancy. Discontinue treatment if there is evidence of tumour growth. Monitoring in patients with scoliosis is recommended due to risk of progression of scoliosis.
Adverse Drug Reactions Hypothyroidism, peripheral oedema; headache; muscle and joint pain; benign intracranial hypertension. Loss of glycaemic control in diabetics.
Drug Interactions High doses of corticosteroid may inhibit growth-promoting effects of GHRP-2.