|Contents||Vial: IGF1 DES (Somatomedin C) 1mg for IM or SC use.
Ampoule: Sterile water for injection 2ml.
|Administration||Intramuscular or subcutaneous injection.|
|Storage||Store at room temperature away from heat and direct sunlight prior to reconstitution. Refrigerate between 2-8’C post reconstitution.|
|Dosage||Adult: SC IGF 1 deficiency Initial: 4 mcg/kg/day. May increase dose gradually. Max: 10 mcg/kg/day. HIV-associated wasting or cachexia 5 mcg/kg/day at bedtime. Can be administered multiples times a day.|
|Contraindications||Acute critical illness due to heart or abdominal surgery, multiple accidental trauma or respiratory failure; active neoplasms, proliferative or preproliferative diabetic retinopathy; lactation; patients with closed epiphyses. Intracranial lesions. Patients with Prader-Willi syndrome who are severely obese or have severe respiratory impairment.|
|Special Precautions||Monitor thyroid function; benign intracranial hypertension. DM; may require dose reduction in insulin. Pregnancy. Discontinue treatment if there is evidence of tumour growth. Monitoring in patients with scoliosis is recommended due to risk of progression of scoliosis.|
|Adverse Drug Reactions||Hypothyroidism, peripheral oedema; headache; muscle and joint pain; benign intracranial hypertension. Loss of glycaemic control in diabetics.|
|Drug Interactions||High doses of corticosteroid may inhibit growth-promoting effects of IGF1 DES.|
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